Proteases in Pemphigoid Diseases

Pemphigoid diseases: pathogenesis, diagnosis, and treatment.

Pemphigoid diseases (including bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA dermatosis, lichen planus pemphigoides, and anti-p200 pemphigoid) are a subgroup of autoimmune bullous skin diseases characterized by an autoantibody response toward structural components of the hemidesmosome resulting in subepidermal blistering. By the use of different in vitro sys...

Association between bullous pemphigoid and internal diseases.

Effectiveness and Safety of Rituximab in Recalcitrant Pemphigoid Diseases

Introduction Rituximab (RTX) is a monoclonal antibody targeting CD20, a transmembrane protein expressed on B cells, causing B cell depletion. RTX has shown great efficacy in studies of pemphigus vulgaris, but data of pemphigoid diseases are limited. Objective To assess the effectiveness and safety of RTX in pemphigoid diseases. Methods The medical records of 28 patients with pemphigoid dise...

Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases

Regulatory T cells (Tregs) are well known for their modulatory functions in adaptive immunity. Through regulation of T cell functions, Tregs have also been demonstrated to indirectly curb myeloid cell-driven inflammation. However, direct effects of Tregs on myeloid cell functions are insufficiently characterized, especially in the context of myeloid cell-mediated diseases, such as pemphigoid di...

Targeting proteases in cardiovascular diseases by mass spectrometry-based proteomics.

Proteases hydrolyze peptide bonds, thereby controlling the function of proteins and peptides on the post-translational level. In the cardiovascular system, proteases play pivotal roles in the regulation of blood pressure, coagulation, and other essential physiological processes. Accordingly, proteases are prime targets for therapeutic interventions and diagnostics. Proteases are part of complex...